KMID : 1156220130390060505
|
|
Journal of Environmental Health Sciences 2013 Volume.39 No. 6 p.505 ~ p.512
|
|
Urinary Concentrations of Benzophenones in University Students and Association with Cosmetics Habits
|
|
Oh Seung-Eun
Ho Sung-Wook Kim Hyun-Suk Lee Se-Hoon Park Na-Youn Kho Young-Lim
|
|
Abstract
|
|
|
Objectives: Ultraviolet (UV) radiation may cause skin cancer, photo-ageing, erythema, and sunburn. Benzophenone (BP) is commonly used to protect skin from UV radiation. In Korea, sunscreen, sunblock, socalled ¡®blemish balm¡¯ (BB) and ¡®color correcting¡¯ (CC) creams, and foundation may contain from 0.5 to 5% benzophenone in order to protect skin from UV radiation. The purpose of this study is to understand the levels of benzophenone derivatives in urine among a group of university students and identify the contribution of cosmetics use.
Methods: Forty volunteers (20 women and 20 men) were asked about skin type, frequency of use of cosmetics, and recognition of related health effects, etc. in a survey. Subjects were divided into several subgroups and were compared for concentration of benzophenone-1 (BP-1) and benzophenone-3 (BP-3). Their urine was pretreated with enzyme hydrolysis and solid phase extraction. Determinations of BP-1 and BP-3 in the urine were made with LC-MS/MS.
Results: Among the study subjects, 82.5% used basic cosmetics at least once per day, and 77.5% used sunscreens at least once per day. The concentrations of BP-1 and BP-3 of the males were 4.36 ng/mL and 9.16 ng/mL, respectively. Those of the females were 3.98 ng/mL and 5.07 ng/mL, respectively. The use of cosmetics was positively related to urinary benzophenone levels.
Conclusions: BP-1 and BP-3 were widely detected among the university students. Cosmetic use was identified as a potential source. Implications of such exposure deserve further investigation.
|
|
KEYWORD
|
|
Benzophenones, Cosmetics, Urine, Exposure, LC-MS/MS
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|